Manabu Kinoshita Selected Research

Shwartzman Phenomenon (Shwartzman Reaction)

7/2019	Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction.
6/2009	Novel mechanism of C-reactive protein for enhancing mouse liver innate immunity.
10/2008	IL-15-induced CD8+CD122+ T cells increase antibacterial and anti-tumor immune responses: implications for immune function in aged mice.
3/2006	An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells.
2/2005	Critical role of the liver CD8+ CD122+ T cells in the generalized Shwartzman reaction of mice.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Manabu Kinoshita Research Topics

Disease

32	Neoplasms (Cancer) 01/2022 - 01/2002
20	Infections 10/2021 - 05/2004
13	Glioma (Gliomas) 01/2022 - 01/2005
13	Bacterial Infections (Bacterial Infection) 10/2021 - 10/2002
13	Sepsis (Septicemia) 01/2017 - 01/2004
12	Hemorrhage 06/2022 - 08/2008
12	Glioblastoma (Glioblastoma Multiforme) 10/2021 - 04/2010
12	Wounds and Injuries (Trauma) 01/2021 - 10/2005
12	Burns 01/2019 - 10/2002
8	Brain Neoplasms (Brain Tumor) 09/2021 - 04/2009
7	Shock 01/2020 - 08/2004
6	Peritonitis 01/2021 - 10/2002
6	Septic Shock (Toxic Shock Syndrome) 08/2013 - 01/2004
5	Hemorrhagic Shock 06/2022 - 01/2011
5	Shwartzman Phenomenon (Shwartzman Reaction) 07/2019 - 02/2005
5	Hepatitis 02/2015 - 12/2008
4	Pathologic Constriction (Stenosis) 08/2021 - 03/2008
4	Neoplasm Metastasis (Metastasis) 07/2021 - 08/2007
4	Lymphoma (Lymphomas) 04/2021 - 10/2003
4	Wilms Tumor (Wilm's Tumor) 06/2015 - 04/2010
4	Escherichia coli Infections 09/2013 - 08/2004
4	Arthritis (Polyarthritis) 05/2013 - 03/2010
3	Anemia 06/2022 - 03/2008
3	Fatty Liver 01/2022 - 06/2015
3	Disease Progression 10/2016 - 10/2007
3	Infectious Arthritis (Septic Arthritis) 05/2013 - 03/2011
3	Hypoxia (Hypoxemia) 08/2012 - 10/2007
3	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 06/2012 - 06/2003
3	Stomach Neoplasms (Stomach Cancer) 05/2008 - 01/2006
2	Albuminuria 01/2022 - 12/2021
2	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022 - 12/2021
2	Inflammation (Inflammations) 12/2021 - 12/2020
2	Breast Neoplasms (Breast Cancer) 09/2021 - 08/2006
2	Ulcer 01/2021 - 01/2019
2	Ischemia 02/2020 - 05/2003
2	Stroke (Strokes) 10/2017 - 07/2017

Drug/Important Bio-Agent (IBA)

16	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2021 - 01/2005
12	Interleukin-18 (Interleukin 18)IBA 05/2013 - 10/2002
11	LipopolysaccharidesIBA 10/2021 - 05/2004
9	Biological ProductsIBA 09/2021 - 01/2008
9	CytokinesIBA 02/2013 - 06/2003
8	Hemoglobins (Hemoglobin)IBA 11/2021 - 03/2008
8	Interferon-gamma (Interferon, gamma)IBA 10/2021 - 05/2004
6	Liposomes (Liposome)IBA 02/2022 - 02/2015
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 02/2007
5	Temozolomide (Temodar)FDA LinkGeneric 10/2021 - 05/2010
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2008
5	Therapeutic UsesIBA 01/2016 - 10/2002
5	1-phenyl-3,3-dimethyltriazene (PDT)IBA 05/2013 - 03/2010
5	Immunoglobulin M (IgM)IBA 05/2013 - 10/2006
5	Anti-Bacterial Agents (Antibiotics)IBA 05/2013 - 10/2010
5	Interleukin-10 (Interleukin 10)IBA 02/2013 - 10/2002
5	salicylhydroxamic acid (SHAM)IBA 07/2011 - 05/2004
4	liposome-encapsulated hemoglobinIBA 06/2022 - 08/2008
4	Oxygen (Dioxygen)IBA 06/2022 - 10/2007
4	Adenosine Diphosphate (ADP)IBA 02/2022 - 02/2015
4	Fibrinogen (Factor I)FDA Link 02/2022 - 02/2015
4	Pharmaceutical PreparationsIBA 04/2021 - 02/2006
4	C-Reactive ProteinIBA 01/2021 - 09/2005
4	ErbB Receptors (EGF Receptor)IBA 01/2020 - 01/2016
4	Peptides (Polypeptides)IBA 10/2019 - 02/2015
4	poly(lactide) (polylactic acid)IBA 02/2013 - 11/2009
4	Methionine (L-Methionine)FDA Link 04/2012 - 01/2012
3	AlbuminsIBA 06/2022 - 02/2015
3	AntioxidantsIBA 01/2022 - 02/2007
3	LigandsIBA 01/2021 - 11/2008
3	Polysaccharides (Glycans)IBA 07/2013 - 07/2010
3	Interleukin-12 (IL 12)IBA 05/2013 - 10/2008
3	Polymyxin B (Aerosporin)FDA LinkGeneric 02/2013 - 01/2004
3	InterleukinsIBA 06/2009 - 03/2006
3	alpha-galactosylceramideIBA 12/2008 - 10/2005
2	Fatty Acid-Binding ProteinsIBA 05/2022 - 08/2012
2	Hemostatics (Antihemorrhagics)IBA 02/2022 - 02/2015
2	Protein Subunit VaccinesIBA 01/2022 - 01/2021
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2022 - 01/2020
2	CreatinineIBA 12/2021 - 08/2004
2	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 09/2021 - 10/2012
2	human ERBB2 proteinIBA 09/2021 - 08/2006
2	Human Serum Albumin FDA LinkGeneric 01/2021 - 02/2015
2	Activated-Leukocyte Cell Adhesion Molecule (Neurolin)IBA 01/2020 - 10/2012
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 08/2018
2	EnzymesIBA 10/2017 - 04/2008

Therapy/Procedure

19	Therapeutics 01/2021 - 07/2002
11	Radiotherapy 01/2022 - 01/2002
9	Injections 10/2021 - 10/2002
6	Resuscitation 02/2022 - 01/2011
6	Immunotherapy 01/2022 - 04/2010
5	Gastrectomy 07/2013 - 09/2005
5	Photochemotherapy (Photodynamic Therapy) 05/2013 - 03/2010
4	Drug Therapy (Chemotherapy) 01/2016 - 10/2003
3	Hemodilution 06/2022 - 08/2008
3	Ligation 01/2021 - 09/2010
3	Lasers (Laser) 01/2020 - 12/2015
3	Hemoperfusion 02/2013 - 01/2004
2	Intraosseous Infusions 06/2022 - 01/2020
2	Cesarean Section (Caesarean Section) 11/2021 - 07/2009
2	Erythrocyte Transfusion 01/2021 - 11/2015
2	Transplantation 01/2021 - 04/2012
2	Chemoradiotherapy 12/2019 - 01/2014
2	Stents 05/2018 - 10/2017